OTIS 笔试题全英的 Please read the following two sections and complete the questions within 40 minutes. Section 1: Doctors Divided Over Heart Pills A group of drugs now being marketed in the United States under a variety of brand names have been probed to reduce deaths among heart-attack survivors by more than 40% over five years. The drugs are collectively known as statins, and are currently being taken by over 10 million Americans. Doctors are currently wondering if statins will be just as effective in preventing heart attacks in people who do not necessarily fit the profile of a “high-risk” patient. The people the doctors are targeting for possible prescription of statins are those whose LDL, or “bad” cholesterol, is somewhat high, or their HDL, or “good” cholesterol is a little low. Again, maybe they have diabetes, which commonly leads to cardiovascular disease, but do not yet show symptoms of the latter. A study report in the British Medical Journal concluded that statins could reduce by 30% the risk of dying from a heart attack, even among people with normal cholesterol levels and no signs of cardiovascular disease. Leading pharmaceutical companies have gone so far as to petition the US Food and Drug Administration (FDA) to allow consumers to buy some low-dose statins without having to first obtain a physician’s prescription, or “over the counter”. Statins work by partly blocking an enzyme, known as HMG, found in liver that turn some of the food that you eat into cholesterol. The body, in fact, needs some cholesterol to produce hormones and Vitamin D. Excess cholesterol builds up in the arteries, reducing the blood flow and increasing the danger of heart disease. By slowing down the function of the HMG enzyme, statins reduce the amount of cholesterol entering the blood stream, and force the body to draw on the cholesterol already in the arteries to make up the shortfall in its needs. Thus, there is a regular clearing out of cholesterol from the arteries. Doctors emphasize that statins work best when a person adopts a low-fat diet. There are, however, certain drawbacks to statins. Apart from the fact that they are expensive-about $3 per pill, and you would presumably have to take them for the rest of your life—they can cause liver damage or a breakdown of muscle tissue. Anyone taking statins needs to undergo periodic blood tests to check for signs of liver trouble. Most people on the pills report no complaints; those who do commonly list fatigue as the major side-effect. Companies manufacturing dietary supplements became interested in statins when it was discovered that Chinese red yeast fermented on rice contains small amount of the same active ingredient found in statins. They then made a dietary supplement containing this ingredient and publicized it as a wonder drug for preventing heart attacks. The FDA banned its sale over the counter, and the
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